%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% % Loss of phase-locking in non-weakly coupled % inhibitory networks of type-I model neurons % % Journal of Computational Neuroscince, 26(2): 303-320. % Myongkeun Oh and Victor Matveev % Dept Math Sci, NJIT % % Reproduces all activity states shown in Fig. 1 % April 12, 2009 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% global gbarsyn; IC = [-37.7891 -40.2443 0 0 0 0 ]; Period = 260; twindow = Period * 1.2; T = 2 *(Period + twindow); figure(1); set(1, 'position', [250, 500, 640, 320]); options = []; options = odeset(options,'RelTol',1e-6); % Change these parameters to obtain different activity states (see Figs. 1,2) % Parameter array: [ gbarsyn tauSyn tgamma vthresh ] Params = [0.22 1 0.2 -3]; [t,y] = ode45(@MLode, [0 T], IC, options, Params); IC = y(length(t),:); [t,y] = ode45(@MLode, [0 T], IC, options, Params); Vinterval = [-65:2:30]; Yw = 0.5*(1+tanh((Vinterval+8)/6)); i = find(t>twindow/2, 1); while t(i) < T - twindow/2; i = i + 5; subplot('position',[0.1 0.15 0.45 0.78]); hold off; plot(Vinterval, Yw, 'b-', 'linewidth', 2); xlabel('V','fontsize',14); ylabel('w','fontsize',14); hold on; V1 = y(i,1); w = y(i,3); plot(V1, w,'om', 'linewidth', 2); V2 = y(i,2); w = y(i,4); plot(V2, w,'ok', 'linewidth', 2); s = y(i,6); Y = Vnullcline(Vinterval, s); plot(Vinterval, Y, '-m', 'linewidth', 2); s = y(i,5); Y = Vnullcline(Vinterval, s); plot(Vinterval, Y, '-k', 'linewidth', 2); axis([-65 30 -0.02 0.6]); %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% subplot('position', [0.6 0.6 0.37 0.25]); hold off; tt = t - t(i) + twindow/2; vmin = min(y(:,1))*1.1; vmax = max(y(:,1))*1.1; plot([twindow/2 twindow/2], [vmin vmax], 'y-', 'linewidth', 2); hold on; plot(tt,y(:,1),'m-','linewidth',1); plot(tt,y(:,2),'k-','linewidth',1); axis([0 twindow vmin vmax]); title('Voltage: V_1(t), V_2(t)','fontsize',12); %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% smax = max(y(:,5)) * 1.1; subplot('position', [0.6 0.15 0.37 0.25]); hold off; tt = t - t(i) + twindow/2; plot([twindow/2 twindow/2], [0 smax], 'y-', 'linewidth', 2); hold on; plot(tt,y(:,5),'m-','linewidth',1); plot(tt,y(:,6),'k-','linewidth',1); axis([0 twindow 0 smax]); title('Synaptic variables: s_1(t), s_2(t)','fontsize',12); xlabel('time (ms)', 'fontsize', 12); drawnow; end;