BIOL698: Current trends in computational biology
Fall 2004

Instructor:
Usman Roshan, GITC 4301
Ph: 973-596-2872
Office hours: Thu: 1-2, Fri: 11-12:30
usman@cs.njit.edu

Course syllabus (ps) (pdf)

Course plan:
   
Topic
Date
Handouts
Basic molecular biology, sequence alignment, multiple alignment
09/01/04
h1, h2, h3
Sequence alignment heuristics, local search, protein structure prediction
09/08/04
h1, h2, h3, h4, h5=algorithms handout, h6=local search handout
Protein structure prediction I
09/15/04
h1=local search handout#2, h2, h3, h4
Protein structure prediction II
09/22/04
h1=protein structure handout#1, h2=protein structure handout#2, h3=algorithms handout, h4
Quiz #1, Gene expression clustering I
09/29/04
h1 h2 h3 h4 h5=iterated local search clustering handout
Gene expression clustering II
10/06/04
h1 h2 h3
DNA fragment assembly, Hidden Markov Models
10/13/04
h1 h2
EM algorithm, Bayesian networks, Phylogenetics---model based estimation,
10/20/04
h1 h2, h3=EM handout,
Quiz #2, Bayesian network inference, Phylogenetics---distance based reconstruction
10/27/04
disance-based methods handout#1, h2
Phylogenetics---distance based reconstruction
11/03/04
Phylogenetics---Neighbor Joining and Maximum Parsimony, review
11/10/04
Quiz #3, student presentation
11/17/04
(1) Prediction of protein subcellular locations by support vector machines using compositions of amino acids and acimo acid pairs
(Use NJIT on-campus machine to download article via NJIT library)
Student presentations
11/24/04
(1) Protein structure prediction using Rosetta
(2) A comprehensive comparison of multiple sequence alignment programs
Student presentations
12/01/04
(1) Base-By-Base: Single nucleotide-level analysis of whole viral genome alignments
(2) Gene prediction with a hidden Markov model and a new intron submodel
Student presentations
12/08/04
(1)(a) Protein-Ligand Docking as an Energy Optimization Problem
(1)(b) A Detailed Comparison of Current Docking and Scoring Methods on Systems of Pharmaceutical Relevance
(2)Genetic algorithms for protein folding simulations

Papers for further reading:

Protein structure prediction: Docking and drug design: Multiple sequence alignment: Phylogenetics: Bayesian networks: