- qMSAT is a powerful test that directly incorporates sequencing
qualities in association tests with multiple rare variants. It
allows for the adjustment of additional covariates and is robust
towards the inclusion of noncausal variants and variants having
effects with different magnitudes and directions. Furthermore, it
can coherently account for missing genotypes and conjoin in a
principled way individuals or variants sequenced at varying coverage
depths.
- R version of qMSAT can be obtained
here.
- A java version of qMSAT, which accepts variant call in the VCF
format output from
SNVer and GATK, will be
available in near future.
- Z. John Daye, Hongzhe Li, and Zhi Wei. A Powerful Test for
Multiple Rare Variants Association Studies that Incorporate
Sequencing Qualities.
Email: zdaye@upenn.edu and zhiwei@njit.edu
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