The Defense Advanced Research Projects Agency (DARPA) was established in 1958 to prevent strategic surprise from negatively impacting U.S. national security and create strategic surprise for U.S. adversaries by maintaining the technological superiority of the U.S. military. To fulfill its mission, the Agency relies on diverse performers to apply multi‐disciplinary approaches to both advance knowledge through basic research and create innovative technologies that address current practical problems through applied research. As the DoD�s primary innovation engine, DARPA undertakes projects that are finite in duration but that create lasting revolutionary change. The Defense Sciences Office (DSO) is one of six technical offices at the agency. DSO identifies and pursues high‐risk, high‐payoff fundamental research initiatives across a broad spectrum of science and engineering disciplines including materials science, computing and autonomy, engineering design and manufacturing, physics, chemistry and pure and applied mathematics. This presentation will give an overview of DARPA, working with DARPA and the Defense Sciences Office, and description of some of the current activities DSO's program managers are working on.