Breast Cancer: A Biomedical Informatics Perspective

Michael N. Liebman, Ph.D, Executive Director
Windber Research Institute


Abstract

The Windber Research Institute collaborates with Walter Reed Army Medical Center in the Clinical Breast Care Project to study breast cancer in the military population and their families. WRI focuses on performing the genomic and proteomic analysis of more than 17,000 breast samples, integration with more than 600 clinical data elements about the patient, images from mammography, ultrasound, PET/CT, MRI and pathology. This comprehensive patient record is analyzed for information content and to develop models for disease progression, risk assessment and enhanced diagnosis and treatment. The informatics challenges are great and ongoing research into data models and data integration, data mining, pattern and image recognition, natural language processing and ontology construction will be presented in this context.