Dr. Rajesh dave

Rajesh N. Davé is a distinguished professor in the Otto H. York Department of Chemical and Materials Engineering.

 

He is the founding Director of the R&D Excellence Center, New Jersey Center for Engineered Particulates, focusing on research and innovations in particle engineering for improved particle properties for applications to pharmaceutical, food, electronics, and energy industries. Under his direction, the center has developed into an important resource for researchers and industry alike in the areas of nanoparticles and nanocomposites. The center is equipped with state-of-the-art equipment for processing and characterizing particles at the nano and submicron levels, and researchers work in partnership with industry to develop tailored particulate materials with unique properties for industry applications. Center research in particle engineering has led to attracting funds from National Science Foundation, National Institute of Health, and other federal agencies as well as industry. These activities have also led to NJIT’s first ever participation in an NSF funded Engineering Research Center on Structured Organic Particulate Systems with a focus on improved materials and manufacturing science for pharmaceutical products. In this NSF-ERC, Prof. Davé is a Site Leader, a Research Thrust Leader and a leader of a particle engineering based technology platform Testbed on drug laden thin films.

 

His NSF-ERC leadership roles have led to significant impact on pharmaceutical industry through aligning high quality research with the NAE and NIH goals that include better medicines, medications the body can absorb and process efficiently, and designing therapies and dosages that are more precise and flexible. These advancements are expected to have a broad societal impact through improved patient care, patient compliance and comfort and reduced manufacturing costs. Ongoing commercialization activities of transformative technologies are expected to make an impact in a long run at a level of over $B per year.

 

His research contributions to date include over 150 journal papers, numerous invited and keynote presentations as well as nine issued and about dozen pending patents. His current research expertise includes engineered particulates with special emphasis on pharmaceuticals products. He has granted 29 PhDs to students at NJIT, six of those students are currently in US academia. He has received numerous awards, most recently, the Board of Overseers Excellence in Research Prize and Medal, NJIT, October 2016 and the Thomas Alva Edison Patent Award Winner, Enabling Technology, November 2016. He has also been engaged in technology development and transfer activities in film coating of very fine particles, bioavailability enhancement, and taste-masking. His work on taste-masking via solventless coating technology has been commercially licensed by a global pharma company.

Dr. Ecevit bilgili

Dr. Ecevit Bilgili is currently an associate professor of Chemical Engineering at NJIT. His Particle Engineering and Pharmaceutical Nanotechnology Lab has been conducting research in designing particulate formulations and processes for high-value-added products like pharmaceuticals with enhanced functionalities such as enhanced bioavailability of poorly water-soluble drugs. His research interests center on the development of a fundamental understanding of the mechanisms–transformations involved during the formation of drug nanoparticles via top-down and bottom-up approaches, nanocomposite microparticles, and amorphous solid dispersions. His research group uses experimentation coupled with population balance modeling (PBM), discrete element modeling (DEM), and microhydrodynamic modeling in a unique multi-scale approach to elucidate complex non-linear rate processes. Prior to this academic position, Dr. Bilgili worked as Principal Development Engineer within R&D and Pharmaceutical Commercialization Technology Department at Merck & Co., Inc during 2004–2009. Before Merck years, he had worked as a post-doctoral research associate at the Particle Engineering Research Center, University of Florida.

 

Dr. Bilgili is a well-recognized member of the Particle Technology Community. He served as an elected Executive Committee Member of the Particle Technology Forum of AIChE. He also served as the Chair & Vice-Chair of AIChE Area3a: Particle Production and Characterization and as a project leader for Project A1: Particle Formation within the NSF ERC for Structured Organic Particulate Systems. He has authored 70 peer-reviewed journal articles, 4 U.S. patents (two recently filed), 2 provisional patents, and several invention disclosures. He delivered 85 national/international presentations and 24 invited talks. He has served as a referee to 20 engineering and pharmaceutics journals, as a chair/co-chair in 32 sessions of national/international conferences, and as a senior member of AIChE and ACS. He was one of the organizers of the Topical Conference titled “Pharmaceutical Engineering for the 21st Century” at the AIChE Annual Meeting in 2007. His research has been funded by NSF ERC, NIH/FDA, Boehringer-Ingelheim, Catalent Pharma Solutions, International Flavors & Fragrances, and Nisso America.

 

Education

Ph.D.(May 2001), Chemical Engineering., Illinois Institute of Technology, Chicago, IL.

B.S.(June 1996), Chemical Engineering., Bogazici University, Istanbul, Turkey.

 

Professional Activities

Editorial Board Member, Advanced Powder Technology, Elsevier Journal, Jan.2016–present

Guest Co-Editor, Special Issue titled “Dissolution Enhancement of Poorly Soluble Drugs,” Pharmaceutics, in preparation, May 2018

Guest Co-Editor, Special Issue titled “Pharmaceutical Powders: Towards Developing Understanding of the Influence of Materials and Processes on Product Performance,” Powder Technology, Vol. 236, February 2013

Programming Chair, Area 3a (Particle Production and Characterization), AIChE Particle Technology Forum, 2010–2011

Executive Committee Member, Elected by the Particle Technology Forum (PTF) Members of AIChE, 2006–2010

Programming Vice Chair, Area 3a (Particle Production and Characterization), AIChE Particle Technology Forum, 2008–2009

 

Honors and Awards

The Newark College of Engineering Faculty Member Award, by NJIT Student Senate, May 2017

The Newark College of Engineering (NCE) 2017 Excellence in Teaching Award, March 2017

NJIT Excellence in Teaching Award in the category “Excellence in Upper Division Undergraduate Instruction by Tenured/Tenure Track Faculty,” September 2015

PCT & GPC Operations Technology Mastery Award, by Merck & Co., in recognition of the efforts towards developing the fluid bed granulation technology, 2009

Marquis Who´s Who in Science and Engineering appeared in the 7th, 9th, and 10th Eds., 2003–2004, 2006–2007, and 2008–2009

Award of Excellence, by Merck & Co., Inc. in recognition of significant contributions to a drug development program, 2008

Award of Excellence, by Merck & Co., Inc. in recognition of significant contributions to an accelerated drug filing, 2006

Special Achievement Award, by Merck & Co., Inc. in recognition of personal dedication and technical contributions to a drug development program, 2005

Best Ph.D. Thesis in Particle Technology Award, by Particle Technology Forum of the American Institute of Chemical Engineers, 2004

Certificate of The Highest Standards of Academic Achievement given by IIT, Chicago, 2001

The Professor Turgut Noyan Award, by the Chemical Engineering Department, Bogazici University, 1996

Alireza naseri

Alireza T. Naseri is a postdoctoral research associate whose research interests include:

• Multiscale and multiphysics modeling for rational design of advanced materials

• Data-driven modeling and optimization for drug design and manufacturing

• Advanced materials characterization and thin films processing

• Kinetics and reaction Engineering

Dr. Naseri has a few years of research experience in multiscale and multiphysics modeling, reaction engineering, material characterization and process optimization. He is currently working on drying and dissolution modeling for continuous manufacturing of polymer strip films, which is funded by FDA/NIH.  Polymer strip films are promising candidates for oral delivery of poorly water-soluble drugs. Drying has significant effect on the quality and performance of the strip films. Kinetic data analysis as well as detailed transport modeling of the drying process is necessary to elucidate the effect of process parameters and optimize the drying condition.

Controlled release of the drug is a critical part of the pharmaceutical product development. Predictive modeling is crucial to capture the complex underlying physics of drug dissolution from polymer strip films. In our group, data-driven modeling is done using CFD software packages as well as in-house codes for optimal design of strip films.

Alireza is also interested in sport and visual arts. He enjoys horseback riding, traveling and he has been involved in film critics groups.

 

PhD: Queen’s University, Canada

MSc: The University of Edinburgh, UK

BSc: Sharif University of Technology, Iran

Hossein Amini

Hossein Amini is a postdoctoral research associate in Computational Science and Engineering, with a Chemical/Biochemical Engineering background.

 

As a postdoctoral research associate at in NJIT’s School of Chemical Engineering, he is working on population balance equation (PBE) modeling, to simulate pharmaceutical fluidized bed granulation process. The purpose of this project is to develop a coupled model in MATLAB that integrates PBEs with heat/mass transfer equations, along with hydrodynamic parameters obtained through solving computational fluid dynamics (CFD) models, developed in Ansys Fluent.

 

Hossein received his Bachelor’s degree in Chemical Engineering in 2009 from Arak University, Arak, Iran. He finished his Master’s degree in Chemical Engineering in 2011, from Amirkabir University of Technology, Tehran, Iran.

 

Based on a national entrance exam that is held every year in Iran for all levels of education, he received free tuition awards for both his BS in 2005 and his MS degree in 2009.

 

Along with an engineering life, Hossein is passionate about learning new languages (French, Arabic, English), professional life style photography, playing music (Persian musical instrument), and running (half marathon).

Eylul Cetindag

Eylul Cetindag works with strip-films for drug delivery (Drying kinetics of films under varying heating modes, effects of casting techniques on the critical quality attributes of films, biorelevant dissolution methods for films)

 

BS-Food Engineering-Hacettepe University-Ankara,Turkey-2012

MS-Micro and Nano Technology, TOBB University of Economy and Technology- Ankara,Turkey-2015

PhD-Chemical Engineering, NJIT- Newark,NJ-2020

liang chen

Liang Chen received his BS from China University of Petroleum in 2011 then worked as process engineer for one and half years in a coal company. He received his MS from New Jersey Institute of Technology in 2015 and started his Ph.D in 2015.   He is studying dry particle coating on improving the manufactural properties of pharmaceutical powders. He has developed a new grade of excipient which has good flowability, high bulk density as well as excellent compaction property by dry coating nano-silica particles onto the surface of microcrystalline cellulose.  He is investigating the application of novel excipients on different active pharmaceutical ingredients with different properties (APIs). He also investigates predictive model to understand tablet properties. His work will be used to simplify the operating processes, improve product formulations, and develop new products.

 

PUBLICATIONS & PATENTS

1. Rajesh N. Dave, Liang Chen. Dry coated engineering excipients. U.S patent application No. 62/378,384, pending.

2. Liang Chen, Xiaoyi Ding, Zizhou He, Zhonghui Huang, Kuriakose T. Kunnath, Kai Zheng, Rajesh N. Dave. Surface engineered excipients: I. Improved functional properties of fine grade microcrystalline cellulose. International Journal of pharmaceutics.(under review)

Guluzar Gorkem

Guluzar G. Buyukgoz is studying the starting materials to be used in the pharmaceutical applications. Specifically, the materials that comprise polymer solutions, active pharmaceutical ingredients (APIs) and excipients. The first important step of producing consistently uniform pharmaceutical products is the mixing of the ingredients that lead to form the end product. In this step, the mixing process is crucial. Guluzar examines the effect of mixing on the end product by dealing with the processing parameters via batch and continuous mixers. In addition, she utilizes engineering particulates, i.e. micronized, dry coated, crystalline form. The engineered particles provide increased surface area and prevent agglomeration, which in turn enables to fabricate enhanced quality of uniformity as well as improved bioavailability. The second step would be characterization of end products by examining the strip films and 3D-printed drugs.

 

EDUCATION

Hacettepe University, Turkey, BS, 2012

Hacettepe University, Turkey, MS, 2014

New Jersey Institute of Technology, USA, Ph.D., 2020

Kuriakose kunnath

Kuriakose Kunnath is a Chemical Engineering PhD candidate at the New Jersey Institute of Technology (NJIT), from where he also graduated with his bachelor’s degree. Currently, Kuriakose works on developing predictive models to estimate the behavior of dry powder blends for their application in continuous manufacturing. Previously, he has worked with several local industry leading companies to apply dry coating technology and study its ability to improve powder properties. Powder packing and flowability are the major properties currently being investigated and attempting to be predicted via mathematical models. While at NJIT, Kuriakose has won the ISPE NJ Student Poster Presentation Competition (2016 & 2017) and the ERC Undergraduate Book Scholarship (2014). When not working on research, with an expected graduation in May 2020, his hobbies include basketball, soccer, reading and cooking.

Mahbubur Rahman

Mahbubur is working on a Mechanistic, Comparative Assessment of Drug Dissolution from Nanocomposites vs. Amorphous Solid Dispersions (ASDs) Prepared via Spray Drying

 

B.Sc. in Chemical Engineering

Bangladesh University of Engineering and Technology (BUET)

Dhaka, Bangladesh, 2011

 

M.Sc. in Chemical Engineering

North Carolina A&T State University, Greensboro,NC, USA,

Graduation date: 2015

 

PhD in Chemical Engineering

New Jersey Institute of Technology, Newark, NJ, USA

Expected graduation Date: May-2019

Lu is a PhD candidate who works with Dr. Dave. She is studying the incorporation of micronized dry drug powder into polymer films for delivery of poorly water soluble drugs. The polymeric films are one such relatively new dosage form which has been gain much interest from industry and academy.  Lu is designing the application of these films as fast disintegration, for buccal delivery, as well as the thick films to benefit from controlled release system.  She is also comparing the traditional solution casting technique to the novel slurry casting technique which has been well developed by Dr. Dave’s group.

Lu graduated from Beijing University of Chemical Engineering with a BS and New Jersey Institute of Technology with an MS.

She expects to receive her PhD in May of 2018.

Lu Zhang

Kai zheng

Kai is working on solventless taste masking technology/powder processing simulation.  He received his BS in July of 2012 and his MS in July of 2015 and expects to graduate in December of 2019.

 

Kai studies the solventless taste masking technology by high intensity processing. As the name suggests, it avoids the use of liquid plasticizers, solvents, binders and any heat treatment to form continuous polymer film coating onto fine solid particles (50-500µm) proven to be environmentally benign, producing none of the organic (neither gas nor liquid) or aqueous waste streams, which usually occurs in liquid-based processes. Kai optimizes processing conditions to enhance product quality from the vibratory mechanical device. Also, in order to provide deep insights into the understanding of the device performance, Kai uses DEM to simulate the motion of the particles. The numerical information of the particle trajectory and velocity in such device becomes beneficial to estimate its efficiency and capability in advance, coupling with the experimental investigations.