BME 667-001: Systems Studies in Biomedical Engineering


 

Class Hours

Monday

2:30 PM – 5:25 PM

Fenster 640

Office Hours  (GITC 2104)    

Monday

1:00 PM – 2:00 PM

Wednesday

10:00 AM – 11:15 AM

 Or by appointment:  (973) 642-7155  or  rockland@njit.edu

home page:   http://web.njit.edu/~rockland

Text

Khoo, Michael C.K., Physiological Control systems, Wiley Interscience, 2000  ISBN 0-7803-3408-6.

To get a CD of Matlab, you can download it from csd.njit.edu or obtain it from the library.  It is a very large download (over 500 MB) so if you want to download this program, you should do it from the PC mall (where you can burn a CD).   One of the toolboxes of Matlab is Simulink, which we will be using extensively in this course.

To get the examples from Khoo, go to ftp://ftp.ieee.org/uploads/press/Khoo/ .  I would recommend setting up folders in your computer for each chapter, and copying/pasting these files (can also use an ftp program to do this).

There are other links for MATLAB, SIMULINK and other related topics.  They can be found at http://web.njit.edu/~rockland/links.html

Course Description

Prerequisite: undergraduate or graduate course in linear systems. Basic techniques of simulation including digital simulation languages. Physiologic systems of current interest using systems analysis techniques leading to formulation of mathematical, digital computer, or electric circuit models. Systems examined include the circulatory, respiratory or hormonal control systems. Basic techniques of signal processing are explored which are necessary to analyze data from physiologic systems

Course objective

By the end of the course you should be able to do the following:

 


 

Course Outline

 

Week

Week of

Homework

   Examples

   Topics

  1.  

11-Sep

1.2, 1.4

·         Muscle Stretch reflex (5-6)

General introduction to course

Chapter 1 – Intro to Matlab and Simulink – examples

·         Basic definitions (modeling, control systems

·         Dynamic systems

·         Distributed vs. lump parameters

·          

  1.  

18-Sep

Diff. Eq problems

·         Lung mechanics (19)

·         Skeletal muscle (20)

 

Chapter 2 (up to page 24)

·         Electrical/Mechanical equivalence

·         Introduction to Simulink

·         Differential equations (classical method)

·         Simulink use

 

  1.  

25-Sep

2.3, 2.7,

Page 30-33 – examples from web (revise for integration)

Chapter 2 (page 24-26, 30-end)

·         Review of Basic Circuit Laws

·         Linearity

·         Laplace Transforms

·         Solving differential equations using Laplace Transform

 

  1.  

2-Oct

 

·         Simulink web example p. 45

·         Cardiac Output

·         Glucose regulation

Ventilation

Exam 1

 

Assignment (no class after exam)

  1.  

9-Oct

4.3, 4.5

Neuromuscular reflex (p. 91-96) web

Chapter 2 – rest of chapter

·         Circuit Analysis with Laplace Transforms

·         Transfer Functions

·         Impulse response and Convolution

 

  1.  

16-Oct

 

 

Team Assignment – no lecture

(ABET visit)

  1.  

23-Oct

3.2

·         Instructors problems

·         Cardiac output, p.49

·         Glucose, p.55

·         Transfer Algebra

·         Block reduction

Chapter 3

·         Steady State Analysis

  1.  

30-Oct

4.3, 4.5

·         p. 94 example

Exam 2

Chapter 4

·         Time Domain Analysis

·         Feedback and Control

  1.  

6-Nov

I5.2, 5.3

·         Instructor example

Chapter 5 (p. 101-108)

·         Frequency Analysis – part 1

  1.  

13-Nov

Instructor homework

·         Section 5-5 Glucose Insulin

Chapter 5 (remainder) and Chap. 6 (part)

·         Review of Bode analysis

·         Nyquist Criterion for Stability

·         Nyquist Stability with Matlab

·         Nichols chart

 

  1.  

20-Nov

6.1, 6.2

·         p. 150 example

Exam 3

Chapter 6 (part)

·         Stability

·         Root Locus plots

·         Routh Stability Criterion

  1.  

27-Nov

Instructor Homework

Instructor examples

 (teacher notes)  

·         Introduction to LabView

·         Fourier Series and Transform

·         Introduction to Heart Rate Variability

·         Start of in-class project

·          

  1.  

4-Dec

Instructor homework

 

·         Heart Rate Variability – project

·         Sampling/Quantitzation

·         Windowing

·         Filtering

·         Continuation of in-class project

 

 

  1.  

11-Dec

 

 

·         Introduction to non-linear analysis

·         Review

 

 

 

The Course Outline may be modified at the discretion of the instructor or in the event of extenuating circumstances.  Students will be notified in class of any changes to the Course outline and laboratory sessions.

Grading:

Class Participation and Homework

10 %

Presentations

15 %

Tests

50 %

Final Exam

25 %

 

There are three tests during the semester.  The lowest grade will be dropped. However, if you achieve an A for all three tests, you will not be excused from the final.  Students achieving an A on all three tests will receive 5 bonus points that will count for the final grade.There will be no makeup tests – if you miss one test, then that is the test you will drop.

 

Honor Code and Behavior

NJIT has a zero-tolerance policy regarding cheating of any kind and student behavior that is disruptive to a learning environment. Any incidents will be immediately reported to the Dean of Freshman Studies.  In the cases the Honor Code violations are detected, the punishments range from a minimum of failure in the course plus disciplinary probation up to expulsion from NJIT with notations on students' permanent record.  Avoid situations where honorable behavior could be misinterpreted.  For more information on the honor code, go to http://www.njit.edu/academics/honorcode.php

 

No eating or drinking is allowed at the lectures, recitations, workshops, and laboratories.

Cellular phones must be turned off during the class hours.

Structure of the Course

The course will be a blend of teacher instruction, laboratory/computer work, problem solving during class (as well as homework assignments) and presentations.  Students are expected to be an active part of the class.

 Homework

Homework is due the week following the date they are assigned (see syllabus), and must be given to the instructor.  The homework will consist of questions at the end of each chapter and problems assigned by the instructor. 

In addition, starting the first week, problems will be assigned to teams.  While all students should try to solve the problem, the team will be expected to present their solution, as well as lead the class in a 5-10 discussion.

Presentations

Students, as a team, will be given problems during the lecture.  A team will be chosen to present their findings, as well as lead a class discussion, in the problem solution. 

Paper

A paper will be assigned to students during the semester, related to information for the chapters.  Students must develop a PowerPoint presentation that will be 10-15 minutes in length, summarizing the key features/information of this paper, a critique of the paper, and how it relates to the assigned topic.  More information will be given during the first session. 

   

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