Spring 2017 Course Syllabus:  Math 654

 Course Title: Design and Analysis of Clinical Trials Textbook: Clinical Trial Design: Bayesian and Frequentist Adaptive Methods , by Guosheng Yin; Publisher: Wiley; 1 edition (January, 2012); ISBN-10: 0470581719, ISBN-13: 978-0470581711 Prerequisites: Math 665 or equivalent with Departmental approval.

 Course Outline Date Lecture Sections Topic Assignment Week 1 1/23 1 Lecture Notes Introduction to Epidemiology Homework 1 Week 2 1/30 2 Chapter 1 and Lecture Notes Introduction to Clinical Trials Week 3 2/6 3 Chapter 4 and Lecture Notes Phase I Clinical Trials Homework 2 Week 4 2/13 4 Chapter 5 and Lecture Notes Phase II Clinical Trials Week 5 2/20 5 Chapter 2 and Lecture Notes Phase III Clinical Trials Homework 3 Week 6 2/27 6 Chapter 7 and Lecture Notes Randomization Week 7 3/6 7 Sections 6.1-6.3 and  Lecture Notes Sample Size Calculations Homework 4 Week 8 3/13 Spring Recess- No Classes Scheduled Week 9 3/20 MIDTERM EXAM: Monday ~ March 20, 2017 Week 10 3/27 8 Section 6.6 and Lecture Notes Group Sequential Methods (I) Week 11 4/3 9 Lecture Notes Group Sequential Methods (II) Homework 5 Week 12 4/10 10 Lecture Notes Multiple Comparisons Procedures (I) Week 13 4/17 11 Lecture Notes Multiple Comparisons Procedures (II) Homework 6 Week 14 4/24 12 Section 6.7 and Lecture Notes Adaptive Design (I) Homework 7 Week 15 5/1 Lecture Notes Adaptive Design (II) Week 16 5/8 FINAL EXAM: Monday ~ May 8, 2017

 IMPORTANT DATES FIRST DAY OF SEMESTER January 17, 2017 LAST DAY TO WITHDRAW March 27, 2017 LAST DAY OF CLASSES May 2, 2017 FINAL EXAM PERIOD May 5 – 11, 2017

 Assignment Weighting Tentative Grading Scale Homework 30 % A 90 -- 100 Midterm Exam 30 % B+ 85 -- 89 Final Exam 40 % B 80 -- 84 C+ 75 -- 79 C 70 -- 74 F 0 -- 69

Important Departmental and University Policies

Prepared by Prof. Wenge Guo, December 20, 2016