Spring 2017 Course Syllabus: Math 654

 

Course Title:

Design and Analysis of Clinical Trials

Textbook:

Clinical Trial Design: Bayesian and Frequentist Adaptive Methods , by Guosheng Yin; Publisher: Wiley; 1 edition (January, 2012); ISBN-10: 0470581719, ISBN-13: 978-0470581711

Prerequisites:

Math 665 or equivalent with Departmental approval.

 

 

Course Outline

Date

Lecture

Sections

Topic

Assignment

Week 1

1/23

1

 

Lecture Notes

 

Introduction to Epidemiology

Homework 1

Week 2

1/30

2

Chapter 1 and Lecture Notes

Introduction to Clinical Trials

 

Week 3

2/6

3

Chapter 4 and Lecture Notes 

Phase I Clinical Trials

Homework 2

Week 4

2/13

4

Chapter 5 and Lecture Notes

Phase II Clinical Trials

 

Week 5

2/20

5

Chapter 2 and Lecture Notes 

Phase III Clinical Trials

Homework 3

Week 6

2/27

6

Chapter 7 and Lecture Notes 

Randomization

 

Week 7

3/6

7

Sections 6.1-6.3 and Lecture Notes

Sample Size Calculations

Homework 4

Week 8

3/13

 

 

Spring Recess- No Classes Scheduled

 

Week 9

3/20

 

 

MIDTERM EXAM:

Monday ~ March 20, 2017

 

Week 10

3/27

8

Section 6.6 and Lecture Notes 

Group Sequential Methods (I)

 

Week 11

4/3

9

Lecture Notes 

Group Sequential Methods (II)

Homework 5

Week 12

4/10

10

Lecture Notes

 

Multiple Comparisons Procedures (I)

 

Week 13

4/17

11

Lecture Notes 

Multiple Comparisons Procedures (II)

Homework 6

Week 14

4/24

12

Section 6.7 and Lecture Notes

Adaptive Design (I)

 Homework 7

Week 15

5/1

 

Lecture Notes

Adaptive Design (II)

 

 

Week 16

5/8

 

 

FINAL EXAM:

Monday ~ May 8, 2017

 

 

 

 

 

IMPORTANT DATES

FIRST DAY OF SEMESTER

January 17, 2017

LAST DAY TO WITHDRAW

March 27, 2017

LAST DAY OF CLASSES

May 2, 2017

FINAL EXAM PERIOD

May 5 11, 2017

 

Grading Policy

 

Assignment Weighting

 

Tentative Grading Scale

Homework

30 %

 

A

90 -- 100

Midterm Exam

30 %

 

B+

85 -- 89

Final Exam

40 %

 

B

80 -- 84

 

 

 

C+

75 -- 79

 

 

 

C

70 -- 74

 

 

 

F

0 -- 69

 

 

 

Important Departmental and University Policies

 

 

Prepared by Prof. Wenge Guo, December 20, 2016