Spring 2020 Course Syllabus: Math 654
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Course Title: |
Design and Analysis of
Clinical Trials |
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Textbook: |
Clinical Trial Design: Bayesian and Frequentist Adaptive Methods , by Guosheng Yin; Publisher: Wiley; 1 edition (January, 2012); ISBN-10: 0470581719, ISBN-13: 978-0470581711 |
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Prerequisites: |
Math 665 or equivalent with
Departmental approval. |
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Course
Outline |
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Date |
Lecture |
Sections |
Topic |
Assignment |
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Week 1 1/27 |
1 |
Lecture Notes
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Introduction to Epidemiology |
Homework 1 |
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Week 2 2/3 |
2 |
Chapter 1 and Lecture Notes |
Introduction to Clinical Trials |
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Week 3 2/10 |
3 |
Chapter 4 and Lecture Notes |
Phase I Clinical Trials |
Homework 2 |
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Week 4 2/17 |
4 |
Chapter 5 and Lecture Notes |
Phase II Clinical Trials |
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Week 5 2/24 |
5 |
Chapter 2 and Lecture Notes |
Phase III Clinical Trials |
Homework 3 |
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Week 6 3/2 |
6 |
Chapter 7 and Lecture Notes |
Randomization |
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Week 7 3/9 |
7 |
Sections 6.1-6.3 and Lecture Notes |
Sample Size Calculations |
Homework 4 |
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Week 8 3/16 |
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Spring Recess- No
Classes Scheduled |
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Week 9 3/23 |
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MIDTERM EXAM: Monday ~ March 23, 2020 |
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Week 10 3/30 |
8 |
Section 6.6 and Lecture Notes |
Group Sequential Methods (I) |
Clinical Trials Project |
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Week 11 4/6 |
9 |
Lecture Notes |
Group Sequential Methods (II) |
Homework 5 |
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Week 12 4/13 |
10 |
Lecture Notes
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Multiple Comparisons Procedures (I) |
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Week 13 4/20 |
11 |
Lecture Notes |
Multiple Comparisons Procedures (II) |
Homework 6 |
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Week 14 4/27 |
12 |
Section 6.7 and Lecture Notes |
Introduction to Adaptive Design |
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Week 15 5/4 |
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Students’ Project Presentation
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Week 16 5/11 |
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FINAL EXAM: Monday ~ May 11, 2020 |
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IMPORTANT
DATES |
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FIRST DAY OF SEMESTER |
January 21, 2020 |
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LAST DAY TO WITHDRAW |
April 6, 2020 |
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LAST DAY OF CLASSES |
May 5, 2020 |
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FINAL EXAM PERIOD |
May 8 – 14, 2020 |
Grading Policy
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Assignment Weighting |
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Tentative Grading Scale |
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Homework |
25 % |
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A |
90 -- 100 |
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Project |
15 % |
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B+ |
85 -- 89 |
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Midterm Exam |
25 % |
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B |
80 -- 84 |
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Final Exam |
35% |
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C+ |
75 -- 79 |
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C |
70 -- 74 |
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F |
0 -- 69 |
Important Departmental and University
Policies
Prepared by Prof. Wenge Guo, January 13, 2020