Modeling and Analysis of Transdermal Drug Delivery Systems

Modeling and Analysis of Transdermal Drug-Delivery Systems

A major challenge in the pharmaceutical industry is that current drug-delivery methods, such as tablets, injections and sprays, are inefficient in administering long-term consistent drug release to a target site. Certain drugs lose effectiveness over a period of time.
As a result, multiple injections are necessary to maintain the therapeutic level required.  The scientific objective of our group is to introduce new mathematical formulations that ensure accurate, cost-effective polymer-based delivery of
drugs to their target sites. Drug-release profiles can be varied by controlling several factors such as: drug loading, polymer compositions and membrane thickness. Although optimal experimental designs (e.g. sequential simplex delivery method or response surface experiments)
are helpful tools in the development of drug-delivery devices, they are costly and provide only limited predictive capabilities. See http://laurentsimon.com/ for additional information.