Otto H. York Department of Chemical and Materials Engineering


New Jersey Center for Engineered Particulates (NJCEP)


Particle Engineering Laboratory


Research Infrastructure

Poorly Soluble Drugs

Particulate-based systems:  Nanoparticles, Microparticles, Coated Microparticles

Nanosuspensions and Nanocomposites

Strip films

Amorphous solid dispersions:  Spray drying, Impregnation with mesoporous carriers, Amorphization via dry milling

Pharmaceutical Processing

Fluidized bed drying/coating/ granulation

Spray drying

Blending and dry milling

Dry coating

Continuous processing and PAT

Solvent casting/drying

Liquid antisolvent precipitation

Wet stirred media milling

Supercritical fluid processing

Enhancement via Dry-coating

Enhanced direct compression

Better powder flow, compactability, and fluidizability

Improved dry/wet redispersibility and dissolution


Controlled/delayed release


Population balance model

Discrete element model

Microhydrodynamic models

Multi-scale models

Drying models


Dry particle characterization

Particle mixing

York 203

Particle characterization (size, NIR)

Optical imaging

Particle surface characterization

Surface dissolution imaging

York 205

  • Dry coating, sieving
  • Supercritical fluid processing
  • Drying
  • Amorphous stability

York 207

  • Dry coating
  • Fluidized bed drying/coating/granulation
  • Tabletting
  • Wet stirred media milling
  • Texture analysis

York 103

Film casting

Dissolution testing for films, tablets, and composites


Liquid antisolvent crystallization

Particle Engineering Laboratory

York 105

Nanoparticles via wet stirred media milling and melt emulsification

Spray drying for nanocomposites and amorphous solid dispersions

Particle sizing via laser diffraction, thermal analysis (TGA, DSC)

Suspension characterization (rheology, surface tension)

York B-05

Powder characterization (FT4, AOR)

Dry milling/coating (FEM)



Surface modification and dry coating

Fluid Energy Mill

Dry milling/coating of particles

Quadro Mill

Continuous dry coating, dry milling/coating


Dry coating/mixing

Netzsch Mill

Nano/micro-particle suspension formation


Wet vibratory milling with milling media

Micros Batch Mill

Nano/micro-particle suspension formation (in either attrition mode or stirred media mode)

Procept Spray Dryer

Nanocomposites production

Amorphous solid dispersions

Encapsulation, taste masking

Mini Glatt FB Coater

Nanocomposites (~15-800 μm carrier) production

Taste masking/controlled release via polymer coating

Buchi Mini Spray Dryer

Nanocomposites production

Amorphous solid dispersions

Encapsulation, taste masking

Convective/Microwave Drier

Film casting via convection and IR heating

HED Film Casting Line

BCS class II drug delivery platform

Fast dissolving films

Controlled release

Multilayered films

Supercritical Fluid System

Nano/micro particle formation via supercritical fluid processing

Carver Tablet Press

Tablet Making

Sieve Shaker

Particle size screening

Narrow sieve cut preparation


Controlled RH/T for physical stability testing

Patterson Kelley V-Blender

Powder mixing


Dry coating

Sonication Probes

Anti-solvent crystallization, melt emulsificaton

Beckman-LS13320 Particle Size Analyzer

Particle size analysis based on laser diffraction (~40 nm-2000 μm)

Malvern Spraytec Laser Diffraction System

Measurement of particle size in aerosol and droplet size in sprays

Micron Air‑Jet Sieve

Sizing by air-jet sieving

Delsa Nano C

Zeta potential and submicron particle size analysis based on electrophoresis and dynamic light scattering

Sieve Shaker

Sizing by sieving

FT4 Powder Tester

Flow properties (FFC) and bulk density measurement

IGC SEA surface energy analysis

Inverse Gas Chromatography (IGC) surface energy measurement

Sotax Td1

Tap density tester

Hosokawa Powder Tester

Angle of repose


Powder flow ability tester

Sympatec Rodos-Helos

Dry particle size analysis based on laser diffraction

TA-XT Plus Texture Analyzer

Mechanical testing of films

TGA/DSC1/SF Stare system

Thermogravimetric analysis (TGA)

Keyence VH -2500

Digital optical microscope

Polymer DSC, TGA/DSC1/SF Stare system

Differential scanning calorimetry (DSC).

Attension optical tensiometer

Surface tension measurement


Liquid penetration into powder beds

Brookfield viscometer

Apparent shear viscosity

SOTAX AT7 Smart Dissolution SystemTGA/DSC1/SF Stare system

Drug release during dissolution (automated sampling)

Distek 2100C USP II Apparatus

Drug release during dissolution (manual sampling)

DT2 Manual Disintegration Tester

Tablet disintegration testing

Sotax CE7 smart

Flow-through dissolution (automated sampling)

EvolutionTM 60S

UV–visible spectrophotometer

Mettler Compact Karl Fisher Coulometer, C30

Determination of moisture content

Sirius SDI (Surface Dissolution Imager)

Real time UV imaging system

Waters 2695 Separation Module

Drug assay quantification by HPLC

SP-230 Gilson Spinning Riffler

Spinning riffling of powder

Branson B1510

Ultrasonic cleaner


Planetary Centrifugal mixing


Drug assay quantification by HPLC

Fisher Vortex Mixer

Vortex mixing

Nominal fee-based access to Materials Characterization Laboratory (MCL) at NJIT, which houses the following major equipment:


  • Scanning electron microscopy (SEM) with elemental mapping
  • Powder X-Ray diffraction (PXRD)
  • BET surface area, pore size distribution
  • Inductively coupled plasma mass spectroscopy (ICP-MS) Scanning probe microscope/atomic force microscope (SPM/AFM)
  • Fourier Transform Infrared (FTIR) Spectrometer
  • Gas chromatography (GC)
  • Miscellaneous characterization equipment

Research Areas

Facilities and Laboratories

Processing Equipment

Wet Milling: Stirred Media Mill, Attrition Mill, Vibratory Mill

Dry Coating, Dry Milling, and Simultaneous Dry Coating/Milling

Spray Drying and Encapsulation, Wet Coating and Granulation

Strip-Film Production

Miscellaneous Processing Equipment (I)

Particle/Droplet Size Distribution

Powder Characterization Equipment (I)

Miscellaneous Processing Equipment (II)

Characterization Equipment

Powder Characterization Equipment (II)

Solid-State/Thermal/Mechanical Characterization

Suspension Characterization

Dissolution/Disintegration Testing

Drug/Moisture Content Quantification

Sample Preparation Equipment

Additional Facility and Equipment