Poorly Soluble Drugs
Particulate-based systems: Nanoparticles, Microparticles, Coated Microparticles
Nanosuspensions and Nanocomposites
Strip films
Amorphous solid dispersions: Spray drying, Impregnation with mesoporous carriers, Amorphization via dry milling
Pharmaceutical Processing
Fluidized bed drying/coating/ granulation
Spray drying
Blending and dry milling
Dry coating
Continuous processing and PAT
Solvent casting/drying
Liquid antisolvent precipitation
Wet stirred media milling
Supercritical fluid processing
Enhancement via Dry-coating
Enhanced direct compression
Better powder flow, compactability, and fluidizability
Improved dry/wet redispersibility and dissolution
Taste-masking
Controlled/delayed release
Modeling
Population balance model
Discrete element model
Microhydrodynamic models
Multi-scale models
Drying models
Tiernan-310
Dry particle characterization
Particle mixing
York 203
Particle characterization (size, NIR)
Optical imaging
Particle surface characterization
Surface dissolution imaging
York 205
- Dry coating, sieving
- Supercritical fluid processing
- Drying
- Amorphous stability
York 207
- Dry coating
- Fluidized bed drying/coating/granulation
- Tabletting
- Wet stirred media milling
- Texture analysis
York 103
Film casting
Dissolution testing for films, tablets, and composites
Mixing
Liquid antisolvent crystallization
Particle Engineering Laboratory
York 105
Nanoparticles via wet stirred media milling and melt emulsification
Spray drying for nanocomposites and amorphous solid dispersions
Particle sizing via laser diffraction, thermal analysis (TGA, DSC)
Suspension characterization (rheology, surface tension)
York B-05
Powder characterization (FT4, AOR)
Dry milling/coating (FEM)
Mixing
MAIC
Surface modification and dry coating
Fluid Energy Mill
Dry milling/coating of particles
Quadro Mill
Continuous dry coating, dry milling/coating
LabRAM
Dry coating/mixing
Netzsch Mill
Nano/micro-particle suspension formation
LabRAM
Wet vibratory milling with milling media
Micros Batch Mill
Nano/micro-particle suspension formation (in either attrition mode or stirred media mode)
Procept Spray Dryer
Nanocomposites production
Amorphous solid dispersions
Encapsulation, taste masking
Mini Glatt FB Coater
Nanocomposites (~15-800 μm carrier) production
Taste masking/controlled release via polymer coating
Buchi Mini Spray Dryer
Nanocomposites production
Amorphous solid dispersions
Encapsulation, taste masking
Convective/Microwave Drier
Film casting via convection and IR heating
HED Film Casting Line
BCS class II drug delivery platform
Fast dissolving films
Controlled release
Multilayered films
Supercritical Fluid System
Nano/micro particle formation via supercritical fluid processing
Carver Tablet Press
Tablet Making
Sieve Shaker
Particle size screening
Narrow sieve cut preparation
Microclimate
Controlled RH/T for physical stability testing
Patterson Kelley V-Blender
Powder mixing
Hybridizer
Dry coating
Sonication Probes
Anti-solvent crystallization, melt emulsificaton
Beckman-LS13320 Particle Size Analyzer
Particle size analysis based on laser diffraction (~40 nm-2000 μm)
Malvern Spraytec Laser Diffraction System
Measurement of particle size in aerosol and droplet size in sprays
Micron Air‑Jet Sieve
Sizing by air-jet sieving
Delsa Nano C
Zeta potential and submicron particle size analysis based on electrophoresis and dynamic light scattering
Sieve Shaker
Sizing by sieving
FT4 Powder Tester
Flow properties (FFC) and bulk density measurement
IGC SEA surface energy analysis
Inverse Gas Chromatography (IGC) surface energy measurement
Sotax Td1
Tap density tester
Hosokawa Powder Tester
Angle of repose
Flowdex
Powder flow ability tester
Sympatec Rodos-Helos
Dry particle size analysis based on laser diffraction
TA-XT Plus Texture Analyzer
Mechanical testing of films
TGA/DSC1/SF Stare system
Thermogravimetric analysis (TGA)
Keyence VH -2500
Digital optical microscope
Polymer DSC, TGA/DSC1/SF Stare system
Differential scanning calorimetry (DSC).
Attension optical tensiometer
Surface tension measurement
Wettability
Liquid penetration into powder beds
Brookfield viscometer
Apparent shear viscosity
SOTAX AT7 Smart Dissolution SystemTGA/DSC1/SF Stare system
Drug release during dissolution (automated sampling)
Distek 2100C USP II Apparatus
Drug release during dissolution (manual sampling)
DT2 Manual Disintegration Tester
Tablet disintegration testing
Sotax CE7 smart
Flow-through dissolution (automated sampling)
EvolutionTM 60S
UV–visible spectrophotometer
Mettler Compact Karl Fisher Coulometer, C30
Determination of moisture content
Sirius SDI (Surface Dissolution Imager)
Real time UV imaging system
Waters 2695 Separation Module
Drug assay quantification by HPLC
SP-230 Gilson Spinning Riffler
Spinning riffling of powder
Branson B1510
Ultrasonic cleaner
THINKY Mixer
Planetary Centrifugal mixing
IKA RO 15
Drug assay quantification by HPLC
Fisher Vortex Mixer
Vortex mixing
Nominal fee-based access to Materials Characterization Laboratory (MCL) at NJIT, which houses the following major equipment:
- Scanning electron microscopy (SEM) with elemental mapping
- Powder X-Ray diffraction (PXRD)
- BET surface area, pore size distribution
- Inductively coupled plasma mass spectroscopy (ICP-MS) Scanning probe microscope/atomic force microscope (SPM/AFM)
- Fourier Transform Infrared (FTIR) Spectrometer
- Gas chromatography (GC)
- Miscellaneous characterization equipment