Demo Scripts Example script files with comments, in lieau of a tutorial. Hopefully, enough to get you started.

CalC Scripts for Published Models:

1.    V. Matveev, R. Bertram, A. Sherman (2011)
Calcium Cooperativity of Exocytosis as a Measure of Calcium Channel Domain Overlap.
Brain Research 1398: 126-138.
  Full Text     PDF   Scripts

2.    V. Matveev, R. Bertram, A. Sherman (2009)
Ca2+ current vs. Ca2+ channel cooperativity of exocytosis.
Journal of Neuroscience 29(39):12196-12209.
Full Text PDF Scripts

3.    A.M. Weber, F.K. Wong, A.R. Tufford, L.C. Schlichter, V. Matveev, and E.F. Stanley (2010)
N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release.
Nature Neuroscience 13: 1348-1350.
  Full Text   Scripts

4.    L.N. Cornelisse, R.A.J. van Elburg, R.M. Meredith, R. Yuste, and H.D. Mansvelder (2007)
High Speed Two-Photon Imaging of Calcium Dynamics in Dendritic Spines: Consequences for Spine Calcium Kinetics and Buffer Capacity. PLoS ONE 2(10): e1073.
Full Text Scripts

5.   O. Babich, V. Matveev, A. L. Harris, R. Shirokov (2007)
Ca2+-dependent inactivation of CaV1.2 channels prevents Gd2+ block: does Ca2+ block the pore of inactivated channels? Journal of General Physiology, 129: 477-483.
Full Text PDF Scripts

6.   V. Matveev, R. Bertram, A. Sherman (2006)
Residual Bound Ca2+ Can Account for the Effects of Ca2+ Buffers on Synaptic Facilitation
Journal of Neurophysiology, 96: 3389-3397.
Full Text PDF Scripts

7.   Nguyen V, Mathias R, Smith GD (2005)
A stochastic automata network descriptor for Markov chain models of instantaneously coupled intracellular Ca2+ channels. Bull Math Biol, 67(3):393-432.
Full Text Script
The script markov.par (linked above) demonstrates the use of Markov variables to simulate stochastic Ca2+ channel gating, examining the coupling of two stochastic Ca2+ channels with 4-state gating kinetics by Nguyen et al. (2005).
8.   V. Matveev, R.S. Zucker, A. Sherman (2004)
Facilitation through Buffer Saturation: Constraints on Endogenous Buffering Properties
Biophysical Journal, 86:2691-2709
Full Text PDF Scripts

9.   V. Matveev, A. Sherman, R.S. Zucker, (2002)
New and Corrected Simulations of Synaptic Facilitation
Biophysical Journal, 83:1368-1373. <
Full Text PDF Scripts

10.   Yamada, W.M., and R.S. Zucker (1992)
Time course of transmitter release calculated from simulations of a calcium diffusion model.
Biophysical Journal, 61:671-682.
Full Text Script
The script YamadaZucker.par (linked above) reproduces Fig. 3B of Yamada and Zucker (1992)

This material is based upon work supported by the National Science Foundation grant 0417416 and 0817703.
Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author and do not necessarily reflect the views of the National Science Foundation

Victor Matveev
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Last modified: Aug 8, 2012