CalC ("Calcium Calculator") is a free (GNU copyleft) modeling tool for simulating intracellular calcium diffusion and buffering. CalC solves continuous reaction-diffusion PDEs describing the entry of calcium into a volume through point-like channels, and its diffusion, buffering and binding to calcium receptors.

New: CalC version 7.0 implements cooperative calcium buffers
New: CalC version 7.4 implements binary file output
New: CalC version 7.6 implements non-linear membrane pump
New: CalC version 7.7 implements spherical enclosures and obstacles
New: CalC version 7.7.2 implements space-dependent calcium uptake
New: CalC version 7.8 implements arbitrary volume shapes and 2D surface plots
New: CalC version 7.8.4 improved and optimized adaptive time-step control

CalC versions 6.x.x mirror versions 7.x.x, but allow simple (1-to-1) Ca2+ buffers only, and therefore run faster; use them whenever cooperative buffers are not needed

Installation instructions: README

Adaptive time-step method bug fixed in versions 6.X.X (thanks to Christian Stricker for reporting)
VersionCa2+ buffers: Source: Executables:
Release 7.8.8 Apr 7, 2018 Cooperative UNIX MSDN C++ Win64 OS X 10.9.8 OS X 10.13.4
Release 6.8.9 Apr 9, 2018 Simple (faster code) UNIX MSDN C++ Win64 OS X 10.11.5 OS X 10.13.4
[ Link to full descriptions of all CalC release updates ]

CalC Features:
CalC is provided on an as-is basis. I will respond to any bug reports or technical questions, in due course. If you use CalC in your published work, please cite our 2002 Biophys J article, and please send me a reference for inclusion in the CalC publication list upon publication.

Supported in part by the National Science Foundation grants 0417416, 0817703 and 1517085. However, NSF bears no responsibility for any findings, recommendations or conclusions provided by this material.
Last modified: May 19, 2016             Maintained by Victor Matveev