CalC ("Calcium Calculator") is a free (GNU copyleft) modeling tool for simulating intracellular calcium diffusion and buffering. CalC solves continuous reaction-diffusion PDEs describing the entry of calcium into a volume through point-like channels, and its diffusion, buffering and binding to calcium receptors.

New: CalC version 7.0 implements cooperative calcium buffers New: CalC version 7.4 implements binary file output New: CalC version 7.6 implements non-linear membrane pump New: CalC version 7.7 implements spherical enclosures and obstacles New: CalC version 7.7.2 implements space-dependent calcium uptake CalC versions 6.x.x mirror versions 7.x.x, but allow simple buffers only, and therefore run faster; use them whenever cooperative buffers are not needed

Installation instructions: README

Version		Ca2+ buffers:	Source:		Executables:
Version 7.7.4	Mar 17, 2014	Cooperative	UNIX	MSDN C++	Win32	Cygwin	OS X 10.8.5
Version 6.7.4	Mar 17, 2014	Simple (faster code)	UNIX	MSDN C++	Win32	Cygwin	OS X 10.8.5

[ Link to prior CalC versions and updates ]

Versions 7.8 and 6.8 to be released June 2015, featuring an updated numerical engine with improved implementation accuracy of non-rectangular diffusion volumes and diffusion obstacles.

CalC Features:

• CalC is CPU-time efficient and platform-independent (Windows, OS X, Linux, cygwin, etc.)
• CalC is operated by a simple script language with non-trivial flow control, greatly increasing its flexibility.
• CalC is easily combined with MATLAB without any special modifications (see demo).
• CalC allows simulations in any geometry: cartesian 3D, 2D or 1D, polar, spherical, cylindrical, conical, etc.
• CalC allows an arbitrary number of Ca²⁺ buffers, with 1-to-1 and 1-to-2 Ca²⁺ binding.
• CalC scripts may include ordinary differential equations, for instance to model Ca²⁺-dependent exocytosis.
• CalC results can be viewed in real time by piping the output into xmgrace (only on UNIX platforms).

CalC is provided on an as-is basis. I will respond to any bug reports or technical questions, in due course. If you use CalC in your published work, please cite this URL (http://www.calciumcalculator.org) or our 2002 Biophys J article, and please send me a reference for inclusion in the CalC publication list upon publication.

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	This work is supported in part by the National Science Foundation grants 0417416 and 0817703. However, NSF bears no responsibility for any findings, recommendations or conclusions provided by this material.
	Last modified: Jun 5, 2014             Maintained by Victor Matveev