Blood system biology
Blood clot (a.k.a. thrombi) formation and their breakup (a.k.a. embolism) can potentially lead to life-threatening complications when occurring in the heart (i.e., a heart attack), brain (i.e., a stroke), or lungs (i.e., DVT/PE). Among these, thrombo-embolic infarction is the leading cause of mortality and morbidity in the United States, while stroke is the 5th.
Dr. Voronov’s group has done extensive work at the interface of cutting-edge live animal experiments, advanced biomedical imaging and supercomputer blood flow simulations.
1) Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution
RS Voronov, TJ Stalker, LF Brass, SL Diamond
Annals of biomedical engineering 41 (6), 1297-1307
2) A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
JD Welsh, TJ Stalker, R Voronov, RW Muthard, M Tomaiuolo, et al.
3) Hierarchical organization in the hemostatic response and its relationship to the platelet signaling network
Timothy J Stalker, Elizabeth A Traxler, Jie Wu, Kenneth M Wannemacher, Samantha L Cermignano, Roman Voronov, Scott L Diamond, Lawrence F Brass. Blood, blood-2012-09-457739