Bone tissue engineering
Incidences of bone disorders constitute a significant economic burden to societies globally. In the United States alone,over $213 billion is the total annual cost (direct and indirect) of treating the estimated 126.6 million people affected by musculoskeletal disorders. Unfortunately, with an increasingly obese and aging population, this trend is expected to continue further. Current approaches for replacing the damaged bone tissues include the use of bone grafts (ie, auto-grafts or allografts). However, these methods have several shortcomings, limited availability, and risk of disease transmission. To address those disadvantages, bone tissue engineering has emerged as an alternative regenerative strategy.
Prof. Voronov’s group has done extensive work at the interface of cutting-edge artificial bone culturing experiments, advanced biomedical imaging and supercomputer fluid simulations.
- Scaffolds with a High Surface Area-to-Volume Ratio and Cultured Under Fast Flow Perfusion Result in Optimal O2 Delivery to the Cells in Artificial Bone Tissues. Nguyen T.D., Kadri O.E., Sikavitsas VI, and Voronov R.S.
Special Issue (by Invite) “Biomaterials for Bone Tissue Engineering”. Applied Sciences, 2019, 9(11), 2381.
- Numerical Accuracy Comparison of Two Boundary Conditions Commonly used to Approximate Shear Stress Distributions in Tissue Engineering Scaffolds Cultured under Flow Perfusion. OE Kadri, C Williams III, V Sikavitsas, and RS Voronov
International Journal for Numerical Methods in Bioengineering, 2018, 34 (11), e3132
- Image-based modeling: A novel tool for realistic simulations of artificial bone cultures
T. Alam, Q.L. Pham, V.I. Sikavitsas, D.V. Papavassiliou, R.L. Shambaugh, and R.S. Voronov. Technology, 2016, 04 (229).
- Computational modeling of flow-induced shear stresses within 3D salt-leached porous scaffolds imaged via micro-CT
R Voronov, S VanGordon, VI Sikavitsas, DV Papavassiliou
Journal of Biomechanics, 2010, 43 (7), 1279-1286
- Effects of scaffold architecture on preosteoblastic cultures under continuous fluid shear
SB VanGordon, RS Voronov, TB Blue, RL Shambaugh, DV Papavassiliou and V.I. Sikavitsas. Industrial & engineering chemistry research 2011, 50 (2), pp 620–629.